Top 5 CLS Programs in Southern California

by Donna Trang | Posted August 24, 2026

Key Takeaways:

  • CLS programs California students look at should be judged by licensure fit and clinical training.
  • Some of the best clinical laboratory science programs in Southern California are university-based, while others are built inside large hospital systems.
  • The best medical laboratory science programs make it easier to see how coursework connects to hands-on training.

If you’ve recently started researching CLS programs in Southern California, you may have noticed how confusing the wording can be. Clinical laboratory science, medical laboratory science, and medical technology are often discussed in the same way, since they sometimes overlap. However, sometimes they don’t.

It’s important to know the difference here in California because the state’s CLS license is regulated through the CDPH Laboratory Field Services, and some of the best programs are the ones that offer a straight path from prerequisites to training and licensure. 

To help you on your search in starting your program and finding your first employer, we’ve created a list of the five best options for Southern California students, whether you’re going the structured university route or entering a hospital-based training year. 

What to Look for in a California CLS Program

The best programs have three key characteristics:

  • Clear academic structure
  • Visible clinical affiliates
  • Alignment with California licensing requirements

CDPH publishes approved CLS training programs, and some schools also highlight NAACLS accreditation or hospital-based training partnerships.

That’s why the best clinical laboratory science programs and the best medical laboratory science programs should never be judged purely based on ranking. Students need to understand what kind of path they’re stepping into. 

It’s equally important to ask yourself a few questions once you narrow the list.

Are you looking for something degree-based, post-bacc, or training only? Does the program you have your eyes set on explain how clinical training works, or does the format fit where you are academically?

If you’re searching for a “medical laboratory technician schools near me,” it might be worth taking a moment to decide if the MLT path is your actual goal, as it’s not the same thing as the CLS route here in California. 

Top 5 Southern California CLS Programs

  • Loma Linda University

Loma Linda belongs near the top of the Southern California CLS programs list because it has one of the most clearly defined Clinical Laboratory Science (Medical Technology) bachelor’s pathways. The program is offered in a 2+2 format, so students complete their first two years elsewhere and then enter at a junior level.

The structure makes it a great fit for students who already know they want to go the lab-focused route. 

Learn More

  • California State University, Dominguez Hills

The Clinical Science department at CSUDH offers Medical Technology as either a BS degree or a post-baccalaureate certificate. The school also states that the program is NAACLS-accredited and that it has access to affiliated clinical laboratories approved by California’s Department of Public Health.

Among the best medical lab science programs, this is one of the most flexible.

Learn More

  • UCLA Clinical Laboratory Scientist Training Program

UCLA’s program is a post-baccalaureate program, so it’s for students who already have a bachelor’s. Because it’s affiliated with Cal State Dominguez, applicants must apply to CSUDH as post-baccalaureate candidates if not currently enrolled in the CSUDH Medical Technology option, and only 8 students are accepted per year. This intensive year-long program combines hands-on laboratory experience with lectures and cross-departmental training. 

After completing this program, graduates are eligible for the Medical Laboratory Scientist (MLS) certification examination of the American Society of Clinical Pathology (ASCP) Board of Certification (BOC) and for CLS licensure by the California State Department of Health.

Learn More

  • UCI Clinical Laboratory Scientist Training Program

UC Irvine’s year-long post-baccalaureate certificate program provides intensive didactic and clinical instruction, including bench training, formal and informal lectures, and case studies.

Students who complete the program receive a certificate of completion and are eligible to take the certification examination leading to licensure as a medical laboratory scientist by the American Society for Clinical Pathology (ASCP) and for CLS licensure by the California State Department of Health.

Learn More

  • Arrowhead Regional Medical Center

Arrowhead’s School of Medical Technology is another standout Southern California option, particularly for students who want a hospital-based training setting in the Inland Empire. The school is dedicated to graduating qualified Clinical Laboratory Scientists, and its prospective student materials provide insight into how the program operates directly within the clinical laboratory. 

It’s one of the best medical laboratory science programs for students who prefer a more applied setting from the start. 

Learn More

Start Your Career in Southern California

The diversity alone is why so many future lab professionals decide to study in Southern California. With university-linked medical centers and major hospital systems throughout the region, you can compare different training styles and see what works best for you.

Researching CLS programs in California is only the first step. Quality Temp Staffing can help connect you with clinical laboratory opportunities in Southern California when you’re ready to step into the workforce.

Share:
Skip to content